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. 2017 Nov 2;8:1273. doi: 10.1038/s41467-017-01249-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Isothermal titration calorimetry (ITC) shows that sequence effects in coacervation are entropically driven. a The enthalpic contribution to coacervation as a function of τ is small, positive, and does not show significant differences between sequences. Isothermal titration calorimatry captures this thermodynamic value via a fit to an established two-step coacervation model (inset) that distinguishes between enthalpic contributions from ion pairing (IP) and coacervation (Coac) steps⁴⁸. b The entropic contribution to the coacervation free energy is large, negative, and attributed to counterion release. Clear differences are observed as a function of τ, with an increasing entropic driving force with increasing blockiness (larger τ)