Fig. 2.

Strain heterogeneity. A: regional heterogeneity of left ventricular (LV) strain following MI in patients (early post-MI period) was examined using tissue Doppler. Both cyclic longitudinal strain and strain rate exhibited significant variation between the MI and remote regions. The figure was adapted with permission from Edvardsen et al. (36) B: representative strain rate (SR) calculations using tissue Doppler in patients during the early post-MI period (2–6 days post index event), including both peak systolic strain rate (SRs) and early diastolic strain rate (SRe). Trace location is demarcated by line color: Yellow trace denotes basal segment, green trace denotes middle segment, and red trace denotes apical segments. Adapted with permission from Zhang et al. (141) C: representative chord reconstructions of a partial left ventricle in adult sheep, whereby sonomicrometry crystals span the MI, border, and remote regions. Occlusion of the distal segment of the left anterior descending coronary artery yielded an MI within the apical LV region (orange chords). Over time, a significant increase in all these chord lengths was observed. The figure was adapted from Jackson et al. (63) with permission. Although remodeling strain was not calculated, the increases in chord lengths are in line with expected increases in remodeling strains.