Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Oct 20;49(10):e386. doi: 10.1038/emm.2017.150

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

PMC Copyright notice

miR-31a-5p is required for postnatal cardiomyocyte proliferation in vivo. (a) miR-31a-5p antagomirs significantly decreased miR-31a-5p expression in hearts. n=6 per group. (b–d) Antagonizing miR-31a-5p decreased cardiomyocyte proliferation, as shown by 5-ethynyl-2-deoxyuridine (EdU) incorporation (b) and Ki-67 (c) or phospho-histone-H3 (pHH3) staining (d) in cardiomyocytes. At least 2000 cells were quantified in each group. Scale bar: 50 μm. (e) Western blot showed that antagonizing miR-31a-5p reduced proliferating cell nuclear antigen (PCNA) expression, which was paralleled by an upregulation in its downstream target RhoBTB1. n=3 per group.