Table 2.
Association between histologic subtypes and EGFR mutation
| Histologic subtype | N (%) | EFGR | ||
|---|---|---|---|---|
| Mutation | Wild | P | ||
| AIS | ||||
| Yes | 22 (5.8) | 10 | 12 | 0.639 |
| No | 254 (94.2) | 143 | 211 | |
| MIA | ||||
| Yes | 15 (4.0) | 6 | 9 | 0.956 |
| No | 361 (96.0) | 147 | 214 | |
| Lepidic predominant | ||||
| Yes | 38 (10.1) | 21 | 17 | 0.054 |
| No | 338 (89.9) | 132 | 206 | |
| Acinar predominant | ||||
| Yes | 150 (39.9) | 78 | 72 | 0.000 |
| No | 226 (60.1) | 75 | 151 | |
| Papillary predominant | ||||
| Yes | 67 (17.8) | 35 | 32 | 0.034 |
| No | 309 (82.2) | 118 | 191 | |
| Micropapillary predominant | ||||
| Yes | 19 (5.1) | 7 | 12 | 0.726 |
| No | 357 (94.9) | 146 | 211 | |
| Solid predominant | ||||
| Yes | 56 (14.9) | 15 | 41 | 0.022 |
| No | 320 (85.1) | 138 | 182 | |
| IMA | ||||
| Yes | 9 (2.3) | 0 | 9 | 0.012 |
| No | 367 (97.7) | 153 | 214 | |
| Mucinous | 19 (5.1) | 1 | 18 | 0.001 |
| Non‐mucinous | 357 (94.9) | 152 | 223 | |
AIS, adenocarcinoma in situ; EGFR, epidermal growth factor receptor; IMA, invasive mucinous adenocarcinoma; MIA, minimally invasive adenocarcinoma.