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The peptide agonist bound meta-active state of C5aR. (a) The meta-active conformer of C5aR in complex with the peptide agonist illustrated in ribbon diagram. (b) C5aR surface rendered in ionizability mode highlights the YSFKPMPLaR (a=d-Ala) agonist (green) at the “site2”. The crucial pocket on the ECS occupied by the K4 of the agonist is also highlighted.
