Fig. 4.

Evaluating intrinsic disorder in human nuclear proteins by combined binary disorder classifiers, CH-plot [9] and CDF [9], [17], [33]. Here, the coordinates of each point were calculated as a distance of the corresponding protein in the CH-plot from the boundary (Y-coordinate) and an average distance of the respective CDF curve from the CDF boundary (X-coordinate). The four quadrants correspond to the following predictions: Q1, proteins predicted to be disordered by CH-plots, but ordered by CDFs; Q2, ordered proteins; Q3, proteins predicted to be disordered by CDFs, but compact by CH-plots (i.e., putative molten globules or hybrid proteins); Q4, proteins predicted to be disordered by both methods.