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Effects of PGA2, PGE2, PGD2, PGF2α, PGJ2, and PGI2 on EC barrier dysfunction caused by IL-6. A: pulmonary EC pretreated with indicated PG (0.5 µM, first arrow) were stimulated with a combination of IL-6 (20 ng/ml) and IL-6 soluble receptor (SR, 40 ng/ml) as shown by second arrow. Changes in TER were monitored over 15-h time period. B: analysis of EC permeability using XPert assay. Bar graph depicts permeability changes after 6 h of IL-6/SR treatment; n = 5. *P < 0.05 vs. IL-6/SR.
