Figure 2.

Treatment with ASO Recovers SMN Expression and Translation Defects in SMA Tissues

(A) Experimental design.

(B) Representative polysomal profiles obtained from brains (top) and spinal cords (bottom) in each experimental group.

(C) Representative polysomal profiles obtained from CTRL, SMA, and SMA-ASO mouse brains (late symptomatic) and corresponding co-sedimentation profiles from each experimental group for SMN, RPS6, and RPL26.

(D) FRP from CTRL, late-symptomatic SMA and SMA-ASO brains (left) and spinal cords (right) (CTRL, n = 5; SMA, n = 5; ASO, n = 5, ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, two-tailed t test).

(E) Relationship between body weight (left) or righting time (right) and the corresponding FRP, obtained from CTRL, SMA, and ASO-treated mouse brains. Each point corresponds to one mouse. Spearman and Pearson correlations are indicated. (^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, correlation test).

See also Figure S2.