Fig. 2.

Loss of VCAM-1 in satellite cells results in early regeneration defects. A: schematic of tamoxifen treatment and muscle injury. B: representative images of tibialis anterior muscles 7 or 30 days postinjury (DPI). C and D: histogram shows shift to smaller myofiber cross-sectional area (CSA) in Vcam1^−/− muscle compared with Vcam1^+/+ resulting in decreased mean myofiber CSA at 7 DPI. E and F: no difference between Vcam1^+/+ and Vcam1^−/− muscles in either frequency distribution of myofiber CSA or mean myofiber CSA at 30 DPI. Scale bar, 100 µm. **P < 0.01; n = 3 for 7 DPI, n = 5 for 30 DPI.