Fig. 1.

ACY-1215 slows cyst growth and improves renal function in Pkd1^−/− mice. A: representative images of postnatal day (PN) 21 kidney sections from DMSO- and ACY-1215-treated mice (30 mg/kg body wt). No differences were noted in overall body weight (B), but significant reductions occurred in cystic index (C), kidney weight (D), kidney-to-body weight ratio (E), and blood urea nitrogen (BUN, F). The total kidney area and total cystic area were measured with ImageJ (provided by the National Institutes of Health). Cystic index = 100 × (total cystic area/total kidney area) and is expressed as a percentage. Bars represent averages ± SE of DMSO (vehicle)-treated and ACY-1215-treated (n = 5–6) mice. *P < 0.05. Statistical analysis was performed using unpaired 2-tailed Student’s t-test.