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ACY-1215 slows cyst growth and improves renal function in Pkd1−/− mice. A: representative images of PN21 kidney sections from DMSO- and ACY-1215-treated mice (100 mg/kg body wt). A decrease in overall body weight was evident in the treated animals (B); significant reductions occurred in cystic area (C), kidney weight (D), kidney-to-body weight ratio (E), and BUN (F). Experimental details are in Fig. 1. *P < 0.05.
