Effects of sex and UCP1 ablation on whole body indexes of insulin resistance, glycemia, and liver and visceral white adiposity in WT and UCP1 KO female and male mice. A: fasting glucose. B: fasting insulin. C: HOMA-IR. D: AT-IR. E: representative H&E histology images (40× objective) of liver., F: liver TG. G: representative H&E histology images (20× objective) of visceral white AT. H: cell size. Data are expressed as means ± SE. AT, adipose tissue; WT, wild-type; HOMA-IR, homeostasis model assessment of insulin resistance; AT-IR, adipose tissue insulin resistance; TG, triglycerides. *P < 0.05, main effect of sex; $P < 0.05, main effect of genotype. No significant sex × genotype interactions were present. n = 9–13/group.