Table 3.
Pulmonary vascular resistances in lungs from control and CH neonates treated with spermine NONOate
| U-46619 Added to Achieve a Similar Change in Pulmonary Vascular Resistance Between Groups |
U-46619 Added to Achieve a Similar Total Pulmonary Vascular Resistance Between Groups |
|||
|---|---|---|---|---|
| Control | CH | Control | CH | |
| Baseline R | 0.20 ± 0.03 (5) | 0.49 ± 0.04* (5) | 0.2 ± 0.01 (4) | 0.49 ± 0.05* (4) |
| Constricted R | 0.87 ± 0.07 (5) | 1.26 ± 0.09* (5) | 1.13 ± 0.93 (4) | 1.33 ± 0.08 (4) |
| ΔR to U-46619 | 0.67 ± 0.06 (5) | 0.77 ± 0.10 (5) | 0.93 ± 0.08 (4) | 0.84 ± 0.09 (4) |
| ΔR to 10−7 M NONOate | 0.16 ± 0.04 (5) | 0.22 ± 0.09 (5) | 0.25 ± 0.03 (4) | 0.26 ± 0.01 (4) |
| ΔR to 10−6 M NONOate | 0.04 ± 0.11 (5) | 0.16 ± 0.09 (5) | 0.22 ± 0.07 (4) | 0.21 ± 0.10 (4) |
| ΔR to 10−5 M NONOate | −0.53 ± 0.03 (5) | −0.53 ± 0.11 (5) | −0.55 ± 0.06 (4) | −0.63 ± 0.06 (4) |
| ΔR to 10−4 M NONOate | −0.65 ± 0.05 (5) | −0.86 ± 0.14 (5) | −0.88 ± 0.07 (4) | −0.98 ± 0.08 (4) |
Values are means ± SE; n = 4−5 animals/group (shown in parentheses). All experiments were performed in the presence of l-NNA (300 μM). CH, chronic hypoxia; R, resistance (in mmHg·ml−1·kg·min).
*
P < 0.05 vs. control (analyzed by unpaired t-test).