Table 2.

Metabolic cage parameters for normal salt and high-salt diets

	Normal Salt				High Salt
	TG Sham	TG DNx	ETB-def Sham	ETB-def DNx	TG Sham	TG DNx	ETB-def Sham	ETB-def DNx
n	6	5	7	6	6	5	7	6
AP water, ml	18.0 ± 1.0	20.6 ± 0.9	18.9 ± 0.7	20.4 ± 0.5	39.8 ± 2.5†	46.1 ± 1.8†	44.1 ± 2.5†	47.4 ± 3.4†
IP water, ml	5.3 ± 0.4	6.3 ± 0.9	6.2 ± 0.6	4.4 ± 0.4	8.6 ± 0.4†	8.9 ± 0.9	8.7 ± 1.4	6.8 ± 1.1
AP food, g	14.6 ± 0.8	15.5 ± 0.4	15.2 ± 0.4	16.6 ± 0.5	15.3 ± 0.9	17.1 ± 0.6	17.1 ± 1.0	17.7 ± 0.5
IP food, g	4.6 ± 0.5	4.7 ± 0.4	4.8 ± 0.4	4.4 ± 0.7	4.0 ± 0.3	4.1 ± 0.4	4.6 ± 0.7	3.0 ± 0.4
AP urine, ml	5.6 ± 0.6	6.1 ± 0.7	6.3 ± 0.4	6.7 ± 0.5	21.6 ± 1.8†	29.4 ± 2.5*†	25.7 ± 1.8†	26.9 ± 1.5†
IP urine, ml	4.1 ± 0.3	4.8 ± 0.7	4.9 ± 0.5	4.4 ± 0.3	9.2 ± 0.8†	11.1 ± 0.6†	12.0 ± 0.9†	12.1 ± 0.8†
AP Na+, µeq/12 h	877 ± 55	717 ± 67	797 ± 51	796 ± 46	8,132 ± 578†	10,199 ± 1,307†	8,579 ± 655†	8,258 ± 250†
IP Na+, µeq/12 h	666 ± 14	783 ± 42	748 ± 59	710 ± 80	3,592 ± 164†	4,607 ± 297†	4,006 ± 310†	4,123 ± 263†
AP K+, µeq/12 h	1,423 ± 98	1,437 ± 100	1,534 ± 79	1,556 ± 71	2,415 ± 185†	2,731 ± 256†	2,524 ± 170†	2,504 ± 156†
IP K+, µeq/12 h	666 ± 24	707 ± 49	662 ± 60	592 ± 49	843 ± 36	957 ± 71†	938 ± 79†	793 ± 55
AP Cl−, µeq/12 h	1,002 ± 68	850 ± 58	1,031 ± 53	1,015 ± 66	7,862 ± 570†	9,471 ± 1,103†	8,237 ± 660†	8,384 ± 591†
IP Cl−, µeq/12 h	813 ± 25	871 ± 25	873 ± 63	824 ± 95	3,629 ± 141†	4,437 ± 264†	3,837 ± 278†	3,929 ± 223†

Values are means ± SE. TG, transgenic; DNx, denervated; ET_B, endothelin B; AP, active period (zeitgeber time 12–24); IP, inactive period (zeitgeber time 0–12). Two-way ANOVA with Tukey’s and Sidak’s test for multiple comparisons:

^*P < 0.05 vs. TG sham;

^†P < 0.05 vs. normal salt.