Fig. 1.

Effects of chronic oxytocin (OT) infusion into the 3rd ventricle (3V) on energy intake, body weight, and body composition in diet-induced obese (DIO) and chow-fed Long-Evans rats. Ad libitum-fed rats were maintained on the high-fat diet (HFD; 60% of kcal from fat; n = 17–18/group) or chow (n = 6–7/group) for 4.5 mo before receiving continuous infusions of vehicle (Veh) or OT (16 nmol/day). A and E: change in body weight in HFD-fed DIO and chow-fed control animals. B and F: change in body weight gain in HFD-fed DIO and chow-fed control animals. C and G: change in fat mass and lean mass in HFD-fed DIO and chow-fed control animals. D and H: daily energy intake in HFD-fed DIO and chow-fed control animals. Values are means ± SE. *P < 0.05, OT vs. vehicle.