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A HPD for 6 wk following a Western diet (WD) for 12 wk improved sensitivity to intraperitoneal CCK-8S compared with rats remaining on WD. A and B: rats maintained on WD. C and D: rats switched to HPD. Data are means ± SE. Rats per group are indicated at the bottom of each bar. *P < 0.05 vs. 0.0 (saline) and #P < 0.05 vs. 1.8 (CCK-8S dose nmol/kg) (one-way ANOVA).
