Fig. 4.
Dose-response curve of the afferent arteriole (Af-Art) to ANG II. Representative images (A) demonstrated Af-Art constriction induced by ANG II in nondiabetic and diabetic mice. ANG II-induced contraction was significantly enhanced in diabetic mice (B and C; *P < 0.05 vs. nondiabetes). (diabetes: n = 11, nondiabetes: n = 8). AT1 receptor antagonist losartan blocked ANG II-induced (10−12 to 10−6 mol/l) vasoconstriction of the Af-Art in both diabetic and nondiabetic mice. (D and E) (diabetes, n = 7; nondiabetes, n = 6).