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The lipid regulatory pathway based on the nutritional sensing mechanisms. The original pathway, published by Watts in 2009 [3], was expanded to include the findings uncovered by this study (shown in green). Note that only the Δ9 desaturase fat-5 (not fat-6 or fat-7) was investigated. Abbreviations: TGF-β, transforming growth factor-β; SREBP, sterol regulatory element-Binding protein; NHR, nuclear hormone receptor.
