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. 2017 Nov 3;2:17055. doi: 10.1038/sigtrans.2017.55

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Copyright © 2017 The Author(s)

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Toll-like receptor signaling. The MyD88-dependent pathway results in nuclear translocation of NF-κB and induction of pro-inflammatory cytokines. TLR3 and TLR4 activate IRF-3 and induce IFN-stimulated regulatory elements through a MyD88-independent signaling pathway.