REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
rabbit polyclonal anti-UCP1	Abcam	Cat# ab10983; RRID: AB_2241462
Bacterial and Virus Strains
Biological Samples
Chemicals, Peptides, and Recombinant Proteins
bacitracin	Sigma-Aldrich	Cat# B0125; CAS: 1405-87-4
gentamycin	Sigma-Aldrich	Cat# G1914; CAS: 1405-41-0
ciprofloxacin	Sigma-Aldrich	Cat# 17850; CAS: 85721-33-1
neomycin	Sigma-Aldrich	Cat# N6386; CAS: 1405-10-3
penicillin	Sigma-Aldrich	Cat# A70909; CAS: 551-16-6
metronidazole	Sigma-Aldrich	Cat# M1547; CAS: 443-48-1
ceftazidime	Sigma-Aldrich	Cat# C3809; CAS: 120618-65-7
streptomycin	Sigma-Aldrich	Cat# 46754; CAS: 3810-74-0
vancomycin	Sigma-Aldrich	Cat# v2002; CAS: 1404-93-9
Normal rabbit IgG	Santa cruz	Cat#SC-2027
Critical Commercial Assays
ALT assay kit	Catachem Inc	Cat# V165-12
Mouse FGF21 ELISA Kit	R&D Systems	Cat# MF2100
Wako Clinical Diagnostics kits	Wako Life Sciences, Inc	Cat# 994-02891/992-02892; Cat# 990-02991/998-02992; Cat# 464-01601
E.Z.N.A.® Stool DNA Kit	OMEGA bio-tek	Cat# D4015-02
Deposited Data
16S rRNA sequencing data	SRA	accession number # PRJNA398633
Experimental Models: Cell Lines
Experimental Models: Organisms/Strains
Mouse: C57BL/6	Charles River Laboratories	Strain Code: 027
Mouse: Ppara wild-type (Ppara+/+): C57BL/6	(Lee et al., 1995)	N/A
Mouse: Ppara-null (Ppara−/−): C57BL/6	(Lee et al., 1995)	N/A
Mouse: Ppara floxed (Pparafl/fl): C57BL/6	Brocker et al., 2017	N/A
Oligonucleotides
Primers for qPCR, see Table S1	This paper	N/A
Recombinant DNA
Software and Algorithms
GraphPad Prism 7.0	http://www.graphpad.com/	N/A
SIMCA-P+ software 13.0	http://umetrics.com/	N/A
MATLAB	The Mathworks Inc	N/A
MATLAB Script and Data	R script and data for key statistical results	Available upon request to the Lead Contact.
Other