Fig. 4.

TEM analysis of TTR aggregation. TTR Y78F was incubated at 37 °C under stagnant conditions for 4 days in the absence (vehicle) or presence of gallic acid. In panels referring to t=0 days for Vehicle and to t=4 days for gallic acid, arrowheads indicate soluble protein and arrows very small oligomers; in panel referring to t=4 days for vehicle, arrows indicate very large aggregates and arrowheads to small fibrils. Scale bar=500 nm.