Table 4.
Multivariate Regression: Development of Collateral Vessels on the Disk and Within the Retina Over 36 Months
| Disk | Retina | |||||||
|---|---|---|---|---|---|---|---|---|
|
|
||||||||
| BRVO (Including HRVO) | CRVO | BRVO (Including HRVO) | CRVO | |||||
|
|
||||||||
| Baseline Characteristic | Hazard Ratio | P* | Hazard Ratio | P* | Hazard Ratio | P* | Hazard Ratio | P* |
| Treatment group (1 mg) | 1.35 | 0.419 | 0.80 | 0.472 | 0.86 | 0.457 | 0.77 | 0.322 |
| Treatment group (4 mg) | 1.33 | 0.443 | 1.16 | 0.627 | 1.10 | 0.612 | 0.95 | 0.850 |
| Age | 1.02 | 0.325 | 0.98 | 0.117 | 0.98 | 0.014 | 0.98 | 0.035 |
| Female | 0.75 | 0.346 | 1.16 | 0.574 | 0.96 | 0.668 | 0.79 | 0.300 |
| Diabetes | 0.84 | 0.669 | 0.90 | 0.727 | 0.48 | 0.002 | 0.73 | 0.259 |
| Coronary heart disease | 1.04 | 0.926 | 0.83 | 0.578 | 0.83 | 0.369 | 1.07 | 0.829 |
| Systemic hypertension | 0.58 | 0.076 | 1.40 | 0.243 | 1.10 | 0.584 | 1.30 | 0.299 |
| Duration of macular edema | 0.91 | 0.068 | 0.89 | 0.014 | 0.97 | 0.145 | 0.90 | 0.010 |
| Baseline capillary nonperfusion | 1.01 | 0.659 | 1.07 | 0.267 | 1.04 | <0.001 | 1.20 | 0.001 |
| Baseline visual acuity letter score | 0.96 | <0.001 | 0.99 | 0.159 | 1.00 | 0.596 | 0.99 | 0.103 |
| Baseline IOP | 0.95 | 0.252 | 1.01 | 0.798 | 0.98 | 0.344 | 1.00 | 0.981 |
| Baseline lens status (pseudophakic) | 0.89 | 0.784 | 1.21 | 0.599 | 1.57 | 0.047 | 0.97 | 0.932 |
| Area of retinal hemorrhage | 1.19 | 0.010 | 1.04 | 0.269 | 0.93 | 0.070 | 1.05 | 0.172 |
P is from a multivariate Cox regression which estimates the increase in hazard of the presence of collateral vessels on the disk or within the retina associated with the baseline predictor, considered jointly with the other predictors over 36 months.
IOP, intraocular pressure.