Table 2. Unadjusted and Adjusted Difference Scores of BREAST-Q PROs.
| BREAST-Q Survey | Cohort | Unadjusted Scores, Mean (SD) | Adjusted Mean Difference (95% CI)a | |||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 1 y Postoperative | 2 y Postoperative | 1 y Postoperative | P Value | 2 y Postoperative | P Value | ||
| Satisfaction with breast | Fat grafted | 58.7 (21.5) | 60.1 (16.7) | 65.6 (17.1) | −4.74 (−8.21 to −1.28) | .008 | −0.68 (−4.42 to 3.06) | .72 |
| No fat graft | 59.2 (22.5) | 66.1 (17.2) | 66.0 (18.3) | |||||
| Psychosocial well-being | Fat grafted | 68.4 (18.7) | 67.2 (19.3) | 73.2 (19.2) | −3.87 (−7.33 to −0.40) | .03 | −0.59 (−3.92 to 2.74) | .73 |
| No fat graft | 68.8 (18.5) | 73.5 (19.2) | 75.3 (19.1) | |||||
| Physical well-being | Fat grafted | 77.2 (16.0) | 72.5 (13.5) | 74.8 (15.2) | −1.23 (−3.71 to 1.25) | .33 | −0.50 (−3.36 to 2.36) | .73 |
| No fat graft | 78.4 (14.7) | 76.2 (14.9) | 76.8 (14.9) | |||||
| Sexual well-being | Fat grafted | 55.7 (20.3) | 48.0 (20.5) | 52.8 (20.9) | −5.59 (−9.70 to −1.47) | .008 | −2.94 (−7.01 to 1.12) | .15 |
| No fat graft | 54.4 (20.9) | 54.7 (21.0) | 55.4 (21.9) | |||||
Fat-grafted and non–fat-grafted differences based on mixed-effects regression models with each PRO measure at 1 or 2 years postoperatively as the dependent variable. Each model included an indicator for fat grafting between years 1 and 2 as the primary predictor, and included as covariates baseline PRO, age, body mass index, procedure type, laterality, indication for mastectomy, timing of reconstruction, radiotherapy, smoking history, race, ethnicity, fat grafting before year 1 PRO measures, concurrent revision procedure, cancer recurrence, and prior complication. Also included are random intercepts for study sites (hospitals) and an interaction variable between fat grafting and concurrent revision procedures. Analyses were performed and combined using 10 imputed data sets.