Table 2.

The values of basal respiration rate (V₀), maximal rate of respiration (V_m, was calculated from a titration curve after step-wise addition of ADP, up to 2 mM), apparent K_m values for ADP for permeabilized human colorectal cancer and surrounding tissue samples as well as some healthy rat muscle tissues of different histological type.

Tissue	V0	KmappADP, µM	Vm	Source
Colorectal cancera	1.99±0.26	93.6±7.7b	3.82±0.32*	Our data
Nearby tissuec	1.64±0.27	84.9±9.9b	2.98±0.34*	Our data
Healthy colon tissuec	1.13±0.12	256±34b	1.92±0.14	Our data
Rat heart fibers	6.45±0.19	297±35	28.7±1.1	[56], [64]
Rat soleus	2.19±0.30	354±46	12.2±0.5	[56], [64]
Rat gastrocnemius white	1.23±0.13	14.4±2.6	7.0±0.5; 4.10±0.25	[56], [64]

^*significant difference vs. normal intestinal tissue, p<0.05.

^aAll respiratory rates are given as nmol O₂/min/mg dry weight of tissue.

^bThese apparent K_m values were determined by fitting experimental data to a non-linear regression equation (according to a Michaelis–Menten model).

^cNearby and healthy intestinal tissue samples were taken at a site distant from the tumor locus by 2 and 5 cm, respectively.