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. 2017 Nov 2;17:709. doi: 10.1186/s12885-017-3709-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Cisplatin exposure of PDX-derived human breast cancer cells in 3D microfluidic culture. Human cancer cells from two different breast cancer PDX avatars were isolated and seeded in 3D in the OrganoPlate® 1 day prior to 48 h cisplatin exposure. Culture viability was quantified using the luminescent CellTiter-Glo® cell viability assay. IC50 were determined based on nonlinear fit of the dose response range as 8,1 μM and 14,8 μM for PDX-1 and PDX-2 respectively