Table 3.
Factors associated with uncomplicated pregnancies and birth, and their predictive performance
| Univariablea, OR (95% CI) | Multivariable (Clinical factors only), OR (95% CI), n = 1370 | Multivariable (All factors), OR (95% CI), n = 907 | |
|---|---|---|---|
| Maternal age (per 5 year), n = 1409 | 0.90 (0.82–1.00) | 0.79 (0.71–0.88) | 0.81 (0.71–0.93) |
| Multiparous, n = 1409 | 3.22 (2.54–4.07) | 3.54 (2.75–4.55) | 4.23 (3.04–5.88) |
| Previous history of GDM or PE, n = 786 | 0.58 (0.36–0.91) | ||
| SBP (per 10 mmHg), n = 1387 | 0.77 (0.69–0.85) | 0.82 (0.73–0.91) | 0.84 (0.73–0.97) |
| BMI (per 5 kg/m2), n = 1409 | 0.84 (0.74–0.94) | 0.85 (0.74–0.97) | |
| Mid-arm circumference (per 1 cm) n = 1398 | 0.96 (0.94–0.99) | ||
| Sum of skinfolds (per 1 cm), n = 1390 | 0.94 (0.91–0.98) | ||
| Biomarkers | |||
| HbA1c (per 1 mmol/mol), n = 949 | 0.90 (0.87–0.94) | 0.90 (0.86–0.94) | |
| Insulin (per doubling, log2 of mU/L), n = 1017 | 0.86 (0.78–0.94) | ||
| Adiponectin (per doubling, log2 of μg/mL), n = 1013 | 1.34 (1.16–1.56) | 1.40 (1.18–1.66) | |
| gGT (per doubling, log2 of U/L), n = 1015 | 0.78 (0.67–0.89) | ||
| SHBG (per 1 nmol/L), n = 1004 | 1.00 (1.00–1.00) | ||
| AUROC | 0.69 (0.66–0.71) | 0.73 (0.69–0.76) | |
| Internal validation AUROC | 0.68 (0.65–0.71) | 0.72 (0.68–0.76) | |
aIn univariable analyses numbers vary depending on missing data and are given in the first column
AUROC area under the receiver operating characteristic curve, BMI body mass index, GDM gestational diabetes mellitus, gGT gamma-glutamyl transferase, HbA1c haemoglobin A1c, PE preeclampsia, SBP systolic blood pressure, SHBG sex hormone binding globulin