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Boxplots of c-Kit protein (top) and KIT gene (bottom) expression across the two SKCM mutation subtypes (BRAF V600E and V600K) defined by TCGA melanoma working group. The numbers samples for V600K and V600E, respectively, were 13 and 91 for RPPA; and 17 and 124 for RNA-seq. Both RNA-seq and RPPA (protein expression) data were normalized by TCGA; we subsequently applied a log2-transformation to the RNA-seq data before analysis.
