Table 2.

Differentially expressed proteins between V600E and V600K tumors

Protein	V600E tumors			V600K tumors			p-value
	median	mean	No.	median	mean	No.
up-regulated in V600K tumors
eEF2-R-C	−0.196	−0.250	53	0.308	0.316	9	0.003
TFRC-R-V	0.060	0.095	91	0.877	0.807	13	0.019
ERK2-R-E	−0.023	0.001	53	0.193	0.213	9	0.031
AMPK_alpha-R-C	−0.008	0.003	91	0.228	0.174	13	0.031
c-Kit-R-V	0.030	0.224	91	0.990	0.969	13	0.032
PCNA-M-C	−0.091	−0.028	53	0.081	0.195	9	0.040
S6-R-C	0.041	0.022	38	0.327	0.368	4	0.042
Tuberin-R-C	−0.202	−0.366	38	0.560	0.239	4	0.057
down-regulated in V600K tumors
HER3_pY1289-R-C	0.021	0.044	91	−0.066	−0.053	13	0.004
c-Met_pY1235-R-V	0.038	0.056	53	−0.027	−0.049	9	0.017
Rictor_pT1135-R-V	0.042	0.062	91	−0.137	−0.115	13	0.018
IGFBP2-R-V	0.456	0.604	91	−0.337	−0.062	13	0.024
NF2-R-C	0.003	0.037	91	−0.236	−0.178	13	0.028
Caspase-7_cleavedD198-R-C	0.395	0.491	91	−0.594	−0.242	13	0.031
Bak-R-E	−0.077	−0.134	38	−0.392	−0.454	7	0.035
Bid-R-C	0.018	0.090	91	−0.090	−0.043	13	0.054

The negative values were resulted from normalization by TCGA (www.mdanderson.org/). No further normalization/standardization was carried out for data shown here.