Table 4A.

Somatic mutation patterns in BRAF V600E and V600K tumors. The three genes (GNA11, KIT, and PTEN) with significant difference between the two subtypes are highlighted

Mutation	No. V600E tumors with mutations	No. V600K tumors with mutations	No. V600E tumors without mutation	No. V600K tumors without mutation	p-value
ARID2_mut	13	4	111	13	0.13
CDK4_mut	2	0	122	17	1.00
CDKN2A_mut	3	0	121	17	1.00
DDX3X_mut	18	1	106	16	0.47
GNA11_mut	4	3	120	14	0.04
GNAQ_mut	0	0	124	17	1.00
IDH1_mut	3	1	121	16	0.41
KIT_mut	3	3	121	14	0.02
KRAS_mut	0	0	124	17	1.00
MAP2K1_mut	0	0	124	17	1.00
NF1_mut	0	0	124	17	1.00
NRAS_mut	0	0	124	17	1.00
PPP6C_mut	7	1	117	16	1.00
PTEN_mut	5	4	119	13	0.01
RAC1_mut	16	2	108	15	1.00
RB1_mut	4	0	120	17	1.00
TERT_MUT	12	3	112	14	0.39
TP53_mut	3	0	121	17	1.00

Data taken from the Supplementary Table 1 of TCGA publication [2]. p-value was computed using a two-side Fisher exact test.