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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Autoimmunity. 2017 Feb;50(1):4–18. doi: 10.1080/08916934.2017.1280671

Figure 3. Signaling Pathways that regulate GC B cell and Tfh selection in Spt-GCs.

Figure 3

After acquiring antigen, B cells present antigen via MHC II to T cells with cognate T cell receptors (TCRs). Several co-stimulatory molecules are involved in B cell activation that leads to GC formation or in the maintenance of GC B cells. Most of the receptors and co-stimulatory molecules that are involved in Spt-GC formation regulate B cell survival, proliferation, and class switching (CD40, CD80/86, IL4R, IL21R, IFNγR, BAFFR, TLRs), but IL-17R controls the migration of Tfh and GC B cells and SLAM family molecules have co-stimulatory functions.