Table 2.
Predictors of Outcomes Ranked 1 to 5 According to χ2 Value Using Base Variables and BNP (n=5525)
| Outcome | 1st | 2nd | 3rd | 4th | 5th |
|---|---|---|---|---|---|
| Death (397 events) | log2BNP (χ2:203, HR 1.67) | AF (χ2:11, HR 1.60) | NSTEMI (χ2:11, HR 1.41) | Naa (χ2:10, HR 1.08) | HR per 10 (χ2:10, HR 1.17) |
| Cardiovascular death (286 events) | log2BNP (χ2:201, HR 1.82) | HbA1c (χ2:13, HR 1.18) | AF (χ2:13, HR 1.79) | NSTEMI (χ2:9, HR 1.46) | HR per 10 (χ2:9, HR 1.19) |
| MI (473 events) | Prior MI (χ2:46, HR 1.96) | log2BNP (χ2:44, HR 1.23) | NSTEMI (χ2:29, HR 1.66) | Prior stroke (χ2:13, HR 1.69) | PAD (χ2:10, HR 1.52) |
| HF (221 events) | log2BNP (χ2:135, HR 1.80) | BMI per 5 (χ2:34, HR 1.33) | HR per 10 (χ2:17, HR 1.30) | Prior HF (χ2:13, HR 1.82) | Prior MI (χ2:12, HR 1.67) |
| Stroke (115 events) | log2BNP (χ2:23, HR 1.35) | Prior TIA (χ2:13, HR 3.12) | Macroalbuminuria (χ2:11, HR 2.35) | Age per 10 (χ2:9, HR 1.36) | LDL per 10 (χ2:4, HR 1.06) |
Hazard ratios reflect 1 unit changes if nothing else is stated. For log2BNP that translates into a doubling of the untransformed BNP concentrations. Macroalbuminuria: >300 mg albumin excretion/24 hours. All variables are significant, P<0.05. AF indicates atrial fibrillation/flutter; BNP, B‐type natriuretic peptide; HbA1c, glycated hemoglobin; HR, heart rate; LDL, low‐density lipoproteins; MI, myocardial infarction; NSTEMI, non‐ST elevation myocardial infarction at index event; PAD, peripheral artery disease; TIA, transient ischemic attack.
a
1 mmol/L decreases below 140 mmol/L.