. 2017 May 29;6(6):e004743. doi: 10.1161/JAHA.116.004743

Table 4.

Discriminatory Changes in Best Risk Models With and Without BNP and NT‐proBNP

	C Statistics in Each Model (n=5525)
	Base Model	BNP/NT‐proBNP in Model	NRI	IDI
Death (397 events)
BNP	0.77 (74–0.79)	0.82 (0.80–0.84)^a	30.6% (25.2–36.8)^a	5.0% (3.5–7.2)^a
NT‐proBNP		0.81 (0.79–0.83)^a	24.3% (17.4–29.3)^a	3.3% (2.1–5.0)^a
Cardiovascular death (286 events)
BNP	0.77 (0.74–0.80)	0.83 (0.81–0.86)^a	36.0% (27.4–41.4)^a	5.6% (3.4–8.6)^a
NT‐proBNP		0.83 (0.80–0.86)^a	30.9% (21.7–36.9)^a	4.0% (2.4–6.3)^a
MI (473 events)
BNP	0.71 (0.68–0.73)	0.72 (0.70–0.75)^a	14.3% (9.3–19.5)^a	1.2% (0.6–2.1)^a
NT‐proBNP		0.72 (0.67–0.74)^a	10.6% (5.7–16.6)^a	0.8% (0.3–1.6)^a
HF (221 events)
BNP	0.84 (0.81–0.86)	0.87 (0.85–0.89)^a	35.4% (24.7–40.6)^a	5.0% (3.0–7.6)^a
NT‐proBNP		0.87 (0.84–0.89)^a	29.9% (21.8–36.6)^a	3.8% (2.2–5.8)^a
Stroke (115 events)
BNP	0.74 (0.70–0.79)	0.76 (0.72–0.80)	19.3% (8.8–29.9)^a	0.4% (0–1.2)
NT‐proBNP		0.76 (0.72–0.80)	17.2% (6.3–28.1)^a	0.2% (0–0.8)

NRI and IDI summarized as mean percent improvement ±95% CI. BNP indicates B‐type natriuretic peptide; HF, heart failure; IDI, Integrated Discrimination Index; MI, myocardial infarction; NRI, Net Reclassification Index; NT‐proBNP, N‐terminal prohormone B‐type natriuretic peptide.

P<0.05, comparison between base model and BNP/NT‐proBNP model.