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. 2017 May 26;6(6):e004918. doi: 10.1161/JAHA.116.004918

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Observational associations of PAI‐1 and CHD from the literature up until July 2016. This is a forest plot depicting the result of the meta‐analysis based on previous publications for observations of plasminogen activator inhibitor type 1 (PAI‐1) and coronary heart disease (CHD) association. Odds ratio (OR) with 95% CI is the OR of CHD comparing the highest PAI‐1 quantile to lowest PAI‐1 quantile, which is also represented as a point with bar in the plot. The diamond represents the meta‐analysis result using a random effects model. A, PAI‐1‐CHD associations adjusted for age, sex, and ethnic group in each study. B, PAI‐1‐CHD association in models adjusted for multiple CHD risk factors.