Table 2.
Electrocardiographic Characteristics Before and After Initiation of Disopyramide (n=100)
| Pre‐Disopyramide | Post‐Disopyramide (300 mg) | Δ | P Value | |
|---|---|---|---|---|
| Heart rate, bpm ±SD | 61±9 | 65±11 | 4±9.8 | 0.016 |
| PR, ms ±SD | 168±32 | 181±27 | 13±28 | 0.001 |
| QRS, ms ±SD | 105±19 | 109±22 | 4±10 | 0.224 |
| QT, ms ±SD | 424±37 | 435±37 | 10±28 | 0.038 |
| QTcB, ms ±SD | 426±33 | 450±32 | 24±27 | 0.0001 |
| QTcF, ms ±SD | 425±31 | 445±29 | 19±23 | 0.0001 |
| QTcF | ||||
| ≥460 ms | 16 (16) | 33 (33) | ||
| 460 to 479 ms | 12 (12) | 21 (21) | ||
| 480 to 499 ms | 3 (3) | 8 (8) | ||
| ≥500 ms, n (%) | 1 (1) | 4 (4) | ||
QTcB indicates corrected QT interval, Bazett's formula; QTcF, corrected QT interval, Fridericia's formula.