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. 2017 Jun 27;6(6):e005204. doi: 10.1161/JAHA.116.005204

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Hemodynamic responses to interventions associated with the tail‐cuff technique as determined by telemetry. A, Changes in systolic blood pressure (SBP). B, Changes in diastolic blood pressure (DBP). C, Changes in heart rate (HR). Interventions took place within the following periods: presence of the researcher in the room from between 0 and 3 minutes, cage was moved at 0 minute, handling took place between 0 and 1 minute, restraint with and without heating and tail‐cuff started at 0 and lasted until 15 minutes. Values are mean±SEM for 4 animals for each intervention, ^{^^^} P<0.001 moving cage, ^### P<0.001 handling, ***P<0.001 for restraint with and without heating and tail‐cuff intervention compared to baseline measurements using 2‐way‐repeated‐measures ANOVA and Bonferroni post‐hoc comparison test.