Table 1.
Baseline Demographic, Clinical, and Echocardiographic Characteristics of the Study Patients With Severe Aortic Stenosis According to MTPG
| Variable | Overall Population (n=1143) | MTPG 40 to 49 mm Hg (n=426) | MTPG 50 to 59 mm Hg (n=325) | MTPG ≥60 mm Hg (n=392) | P Value |
|---|---|---|---|---|---|
| Demographics, baseline data, and symptoms | |||||
| Age, y | 74±12 | 74±11 | 75±12 | 74±12 | 0.096 |
| Male sex, n (%) | 597 (52.2) | 229 (53.8) | 163 (50.2) | 205 (52.3) | 0.619 |
| BSA, m2 | 1.87±0.2 | 1.87±0.2 | 1.87±0.2 | 1.86±0.2 | 0.822 |
| NYHA, n (%) | |||||
| 1 to 2 | 857 (75) | 324 (76.1) | 244 (72.9) | 296 (75.5) | 0.591 |
| 3 to 4 | 286 (25) | 102 (23.9) | 88 (27.1) | 96 (24.5) | |
| Medical history and risk factors | |||||
| Hypertension, n (%) | 829 (72.5) | 315 (73.9) | 244 (75.1) | 270 (68.9) | 0.128 |
| Diabetes mellitus, n (%,n) | 311 (27.2) | 127 (29.8) | 93 (28.6) | 91 (23.2) | 0.085 |
| Coronary artery disease, n (%) | 588 (51.4) | 216 (50.7) | 183 (56.3)a | 189 (48.2) | 0.090 |
| Past atrial fibrillation, n (%) | 305 (26.7) | 112 (26.3) | 96 (29.5) | 97 (24.7) | 0.343 |
| Charlson comorbidity index | 1.9±1.8 | 2±2.1 | 1.9±1.7 | 1.8±1.7 | 0.138 |
| Echocardiographic parameters | |||||
| Aortic valve | |||||
| Aortic valve area, cm2 | 0.70 (0.58–0.82) | 0.77 (0.64–0.90) | 0.70 (0.59–0.82)b | 0.62 (0.52–0.74)b | <0.001 |
| Aortic valve area indexed to BSA, cm2/m2 | 0.37 (0.32–0.44) | 0.42 (0.35–0.48) | 0.37 (0.32–0.43)b | 0.34 (0.29–0.39)b | <0.001 |
| Peak aortic jet velocity, m/s | 4.6 (4.27–5.0) | 4.2 (4.1–4.3) | 4.6 (4.4–4.7)b | 5.2 (5–5.6)b | <0.001 |
| Transaortic mean pressure gradient, mm Hg | 53 (46–65) | 44 (42–46) | 53 (51–56)b | 70 (64–79)b | <0.001 |
| Stroke volume, mL | 79 (66–92) | 76 (63–90) | 79 (66–91) | 82 (69–96)b | <0.001 |
| Indexed stroke volume, mL/m2 | 42 (36–49) | 41 (34.6–47.6) | 42 (35.5–49) | 44 (38–51)b | <0.001 |
| LV function | |||||
| LV end‐diastolic diameter, mm | 49 (45–54) | 49 (44–54) | 49 (45–54) | 50 (46–53) | 0.376 |
| LV end‐systolic diameter, mm | 30 (26–35) | 30 (26–35) | 30 (26–35) | 30 (27–34) | 0.994 |
| Ejection fraction, % | 64 (59–69) | 63 (58–68) | 64 (60–70) | 65 (60–70)a | 0.024 |
| Indexed LV mass, g/m2 | 132 (108–159) | 121 (101–147) | 131 (104–155)a | 142 (119–169)b | <0.001 |
| LV end‐diastolic volume, mL | 113 (88–153) | 111 (85–151) | 112 (85–149) | 115 (93–160) | 0.298 |
| LV end‐systolic volume, mL | 41 (28–58) | 40 (28–58) | 42 (28–58) | 41 (29–58) | 0.959 |
| E/E′ | 12.2 (8.7–16.9) | 12.2 (8.7–17.1) | 12 (8.5–17) | 12.4 (8.7–16.4) | 0.776 |
| Left atrial volume index, mL/m2 | 41 (31–52) | 41 (30–52) | 40 (31–52) | 41 (32–51) | 0.674 |
| sPAP, mm Hg | 33 (28–40) | 33 (28–40) | 33 (28–41) | 33 (28–40) | 0.953 |
Continuous normally distributed variables are expressed as mean ±1 SD, non‐normally distributed continuous variables are expressed as median (25th and 75th percentiles), and categorical variables as percentages and counts. BSA indicates body surface area; LV, left ventricular; MTPG, mean transaortic pressure gradient; NYHA, New York Heart Association class; sPAP systolic pulmonary artery pressure.
a
P<0.05 individual category vs MTPG 40 to 49 mm Hg.
b
P<0.001 individual category vs MTPG 40 to 49 mm Hg.