Table 3.
Relative Risk of Events (All‐Cause Mortality) of the Study Population With Severe AS and With Asymptomatic or Minimally Symptomatic Severe AS During Follow‐up Associated With MTPG
| MTPG | HR [CI] | P Value | HR [CI] | P Value |
|---|---|---|---|---|
| Severe AS (n=1143) | Asymptomatic or Minimally Symptomatic Severe AS (n=559) | |||
| Univariate analysis | P<0.001a | P=0.211a | ||
| MTPG 40 to 49 mm Hg | Referent group | Referent group | ||
| MTPG 50 to 59 mm Hg | 1.16 [0.87–1.55] | 0.311 | 0.88 [0.55–1.41] | 0.597 |
| MTPG ≥60 mm Hg | 1.30 [1.14–1.49] | <0.001 | 1.17 [0.94–1.47] | 0.164 |
| Multivariate analysis | ||||
| Model 1b | P<0.001a | P=0.042a | ||
| MTPG 40 to 49 mm Hg | Referent group | Referent group | ||
| MTPG 50 to 59 mm Hg | 1.04 [0.76–1.42] | 0.796 | 1.02 [0.61–1.71] | 0.930 |
| MTPG ≥60 mm Hg | 1.32 [1.15–1.52] | <0.001 | 1.29 [1–1.65] | 0.042 |
| Model 2c | P<0.001a | P=0.009a | ||
| MTPG 40 to 49 mm Hg | Referent group | Referent group | ||
| MTPG 50 to 59 mm Hg | 0.99 [0.78–1.27] | 0.958 | 0.99 [0.65–1.49] | 0.949 |
| MTPG ≥60 mm Hg | 1.32 [1.18–1.47] | <0.001 | 1.28 [1.05–1.55] | 0.012 |
AS indicates aortic stenosis; MTPG, mean transaortic pressure gradient.
a
P for global comparison.
b
Model 1: adjustment for age, sex, body surface area, hypertension, coronary artery disease, history of atrial fibrillation, comorbidity index, and ejection fraction.
c
Model 2: adjustment for age, sex, body surface area, hypertension, coronary artery disease, history of atrial fibrillation, comorbidity index, ejection fraction, and aortic valve surgery as a time‐dependent covariate.