Table 4.
Relative Risk of Events (All‐Cause Mortality) of the Study Population With Severe AS and With Asymptomatic or Minimally Symptomatic Severe AS During Follow‐up According to MTPG < or ≥60 mm Hg
| MTPG | HR [CI] | P Value | HR [CI] | P Value |
|---|---|---|---|---|
| Severe AS (n=1143) | Asymptomatic or Minimally Symptomatic Severe AS (n=559) | |||
| Univariate analysis | ||||
| MTPG <60 mm Hg | Referent group | Referent group | ||
| MTPG ≥60 mm Hg | 1.62 [1.27–2.05] | <0.001 | 1.56 [1.04–2.34] | 0.032 |
| Multivariate analysis | ||||
| Model 1a | ||||
| MTPG <60 mm Hg | Referent group | Referent group | ||
| MTPG ≥60 mm Hg | 1.71 [1.33–2.2] | <0.001 | 1.70 [1.10–2.32] | 0.018 |
| Model 2b | ||||
| MTPG <60 mm Hg | Referent group | Referent group | ||
| MTPG ≥60 mm Hg | 1.71 [1.43–2.11] | <0.001 | 1.68 [1.20–2.36] | 0.003 |
AS indicates aortic stenosis; HR, hazard ratio; MTPG, mean transaortic pressure gradient.
a
Model 1: adjustment for age, sex, body surface area, hypertension, coronary artery disease, history of atrial fibrillation, comorbidity index, and left ventricular ejection fraction.
b
Model 2: adjustment for age, sex, body surface area, hypertension, coronary artery disease, history of atrial fibrillation, comorbidity index, left ventricular ejection fraction, and aortic valve surgery as a time‐dependent covariate.