Figure 7.

Neutrophil module: An inflammatory biomarker associated coexpression network is under genetic control of a cis‐eQTL of lipocalin‐2 (LCN2). A, coexpression heatmap (Spearman's correlation) and scaled network connectivity (Methods) of genes composing the neutrophil module in the YFS (n=1650). B, Box plots of age‐ and sex‐adjusted LCN2 expression in individuals with differing dosages of the rs13297295 minor allele (“C”). C, Locus zoom plot of the 1‐MB region around LCN2 showing association on the y‐axis (−log₁₀ P value) between each single‐nucleotide polymorphism (points) and LCN2 expression, recombination rate in the EUR population in that region (blue line underneath the points), and r ² between each SNP and rs13297295 (point color).