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. 2017 Jun 23;6(6):e005973. doi: 10.1161/JAHA.117.005973

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The influence of ANGPTL4 in HDLs on endothelial lipase hydrolysis in humans. Equal amount of HDLs were loaded into endothelial lipase (EL)‐expressing cells for hydrolysis for 4 hours. Before loading, cholesterol, phospholipid, and triglyceride in HDLs were quantified. After loading, medium was collected to measure cholesterol, phospholipid, and free fatty acid. The absolute amounts of metabolized cholesterol and phospholipid and triglyceride were calculated among the subjects with low‐, medium‐, and high‐levels of ANGPTL4 in HDLs in both groups. Metabolized cholesterol (A) and phospholipid (B) were expressed as the fold change when the subjects with medium‐ and high‐levels of ANGPTL4 compared with those having low ANGPTL4 levels in HDLs. n=11 to 12 per subgroup. C, To assess triglyceride metabolism, the ratio of the amount of free fatty acid after hydrolysis vs the amount of triglyceride loaded was calculated. Data are expressed as the fold change when comparing the subjects with the low ANGPTL4 levels in HDLs. n=11 to 12 per subgroup. Significance: ^‡ P<0.0001; ^† P≤0.01. ANGPTL4 indicates angiopoietin‐like protein 4; FFA, free fatty acid; HDL, high‐density lipoprotein; T2DM, type 2 diabetes mellitus.