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. 2017 Jun 23;6(6):e005973. doi: 10.1161/JAHA.117.005973

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Multivariable analysis of the association between ANGPTL4 and HDL components and function. When adjusting for age, sex, body mass index, mean arterial pressure, and lipid‐lowering drugs, the association between the percentage of cholesterol efflux and circulating ANGPTL4 and ANGPTL4 levels in HDLs in both groups (A) is shown. The correlation between ANGPTL4 and cholesterol (B), apoA‐I (C), and SAA (D) in HDLs is shown. Red and blue lines present nondiabetic controls and T2DM patients, respectively. Data are expressed as the change per 1 doubling increase of ANGPTL4 in the circulation (A) or HDLs (A through D). Nondiabetic: n=201; T2DM: n=185. Significance: ^† P<0.01; *P<0.05. ANGPTL4 indicates angiopoietin‐like protein 4; apoA‐I, apolipoprotein A‐I; HDL, high‐density lipoprotein; SAA, serum amyloid A; T2DM, type 2 diabetes mellitus.