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. 2017 Jun 1;6(6):e006042. doi: 10.1161/JAHA.117.006042

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Late administration of CM352 reduced brain damage after intraparenchymal injection of collagenase in rats. A, Analysis of hematoma volume was performed by T2‐weighted magnetic resonance image. Saline (n=6) or CM352 (1 mg/kg, n=6) was administered 3 hours after collagenase injection. B, Hematoma volume was measured at 1 hour, 3 hours, 5 hours, 24 hours, and 14 days after collagenase injection. C, Analysis of hematoma expansion. Functional deficit was evaluated by means of the laterality index (D), and neurological deficit by the Bederson scale (E). Neurologic tests were performed in control (n=6) and CM352‐treated rats (n=6) at 1 day before surgery (baseline), at 24 hours, and 14 days afterward. Data are shown as mean±standard deviation or median [interquartile range]. Differences with control group are denoted as *P<0.05; **P<0.01.