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. 2017 May 31;6(6):e006195. doi: 10.1161/JAHA.117.006195

Figure 6.

Figure 6

Colchicine reduces severity of pulmonary vascular disease in MCT rats. A, Representative hematoxylin and eosin–stained lung sections showing pulmonary arterioles. B, Box‐and‐whisker plots of percentage medial thickness (PBS 13.5±0.6% n=85 arterioles from 3 different animals, MCT 43.4±1.5% n=78 arterioles from 3 animals, MCT‐colchicine 39.5±1.1% n=81 arterioles from 3 different animals). Whiskers extend from 10th to 90th percentiles. Colchicine reduces pulmonary arteriolar medial thickness. C, Colchicine increases PA acceleration time (PBS 33±1 milliseconds, n=16, MCT 17±1 milliseconds, n=21, MCT‐colchicine 22±1 milliseconds n=22). Quantification of (D) mPAP (PBS 12±1 mm Hg, n=5, MCT 41±3 mm Hg, n=13, MCT‐colchicine 29±3 mm Hg n=14) and (E) TPR (PBS 0.1±0.01 mm Hg/[mL·min], n=5, MCT 0.9±0.1 mm Hg/[mL·min], n=9, MCT‐colchicine 0.5±0.1 mm Hg/[mL·min], n=11) from right heart catheterization. Colchicine improves pulmonary hemodynamics. *Significantly different from PBS, #significantly different from MCT rats as determined by 1‐way ANOVA with Tukey post hoc analysis. Scale bar 25 μm. Colch indicates colchicine; MCT, monocrotaline; mPAP, mean pulmonary arterial pressure; PBS, phosphate‐buffered saline; TPR, total pulmonary resistance.