Table 3.

Multivariable Models to Predict Ischemic Cardiac Events

Multivariable Models	Ischemic Cardiac Events
	HR (95% CI)	P Value	χ2	Harrell's C (95% CI)
Clinical model
Age	1.046 (1.03–1.07)	0.000	67.5	0.701 (0.658–0.744)
Diabetes mellitus	1.431 (0.987–2.074)	0.059
Known CAD	1.733 (1.158–2.593)	0.008
ASA	1.522 (0.970–2.389)	0.068
Clopidogrel	1.483 (0.978–2.247)	0.063
Clinical+stress‐echocardiography WM
Age	1.045 (1.025–1.065)	0.000	73.5a	0.720b (0.678–0.763)
Diabetes mellitus	1.383 (0.953–2.006)	0.088
Known CAD	1.775 (1.195–2.637)	0.004
ASA	1.391 (0.881–2.195)	0.157
Clopidogrel	1.310 (0.862–1.989)	0.206
Reversible WM abnormality	1.758 (1.196–2.585)	0.004
Clinical+stress‐echocardiography MP
Age	1.046 (1.026–1.066)	0.000	76.3a	0.723b (0.681–0.764)
Diabetes mellitus	1.409 (0.972–2.041)	0.070
Known CAD	1.810 (1.217–2.693)	0.003
ASA	1.339 (0.847–2.118)	0.212
Clopidogrel	1.299 (0.857–1.969)	0.218
Reversible MP abnormality	1.839 (1.275–2.652)	0.001
Clinical+stress‐echocardiography WM and MP
Age	1.45 (1.025–1.066)	0.000	76.7a, b	0.725b (0.683–0.766)
Diabetes mellitus	1.395 (0.961–2.024)	0.080
Known CAD	1.806 (1.215–2.684)	0.003
ASA	1.335 (0.843–2.111)	0.218
Clopidogrel	1.281 (0.844–1.944)	0.245
Reversible MP abnormality	1.633 (0.971–2.747)	0.064
Reversible WM abnormalities	1.197 (0.695–2.063)	0.517

All patients with inducible WM abnormalities also had reversible MP defect. The last model (WM and MP) with both WM and MP is not significantly more accurate than the previous models with only WM or MP, while they maintain higher Harrell's C and χ² compared with the clinical model. ASA indicates acetylsalicylic acid; CAD, coronary artery disease; HR, hazard ratio; MP, myocardial perfusion; WM, wall motion.

^aMeans P<0.01 all compared with clinical model.

^bMeans P<0.05.