. 2017 May 31;6(6):e006202. doi: 10.1161/JAHA.117.006202

Table 4.

Univariate Analysis of Main Clinical Variables, Medications, and Imaging Parameters as Predictors of Cardiac Ischemic Events, Once Patients Are Divided Based on Whether They Underwent Revascularization or Not After Their Stress Echocardiogram

Ischemic Cardiac Events
Univariate Analysis	Non Revascularized (n=1111)		Revascularized (n=218)
Univariate Analysis	HR (95% CI)	P Value	HR (95% CI)	P Value
Clinical
Age	1.056 (1.034–1.079)^a	0.000^a	1.034 (0.995–1.074)^a	0.087^a
Male sex	1.436 (0.933–2.212)	0.100	0.685 (0.341–1.377)	0.289
Known CAD (MI/PCI/CABG)	3.219 (2.123–4.881)^a	0.000^a	1.049 (0.541–2.036)	0.887
Family history of CAD	1.118 (0.715–1.747)	0.626	0.673 (0.279–1.623)	0.378
Smoke	0.632 (0.363–1.100)	0.104	1.204 (0.564–2.571)	0.631
Hypercholesterolemia	1.169 (0.768–1.779)	0.467	1.195 (0.574–2.488)	0.635
Diabetes mellitus	1.895 (1.231–2.919)^a	0.004^a	1.295 (0.652–2.570)	0.460
Hypertension	1.409 (0.864–2.296)	0.169	0.801 (0.385–1.667)	0.553
Obesity	0.877 (0.467–1.648)	0.683	0.798 (0.244–2.607)	0.709
Drugs
ASA	2.984 (1.798–4.952)^a	0.000^a	0.601 (0.273–1.323)	0.206
Clopidogrel	2.517 (1.577–4.018)^a	0.000^a	1.633 (0.836–3.191)	0.151
β‐Blockers	1.529 (0.993–2.354)^a	0.054^a	0.509 (0.245–1.061)^a	0.071^a
ACE‐I/ARBs	1.567 (1.006–2.440)^a	0.047^a	0.878 (0.411–1.878)	0.738
Statin	1.930 (1.245–2.991)^a	0.003^a	1.066 (0.466–2.441)	0.879
Imaging
Rest LVEF reduction (<50%)	1.905 (1.243–2.920)^a	0.003^a	1.213 (0.594–2.477)	0.597
Reversible WM abnormality	3.585 (2.137–6.014)^a	0.000^a	1.018 (0.462–2.240)	0.965
Fixed WM abnormality	1.291 (0.826–2.017)	0.262	1.187 (0.611–2.306)	0.612
Reversible MP abnormality	2.567 (1.676–3.933)^a	0.000^a	0.859 (0.333–2.216)	0.754
Fixed MP abnormality	1.842 (1.188–2.856)^a	0.006^a	2.181 (1.119–4.247)^a	0.022^a
Reversible WM/MP abnormality	3.990 (2.344–6.793)^a	0.000^a	0.880 (0.339–2.287)	0.794

All patients with inducible WM abnormalities also had reversible MP defect. ACE‐I indicates angiotensin‐converting enzyme inhibitor; ASA, acetylsalicylic acid; ARBs, angiotensin receptor blockers; CAD, coronary artery disease; HR, hazard ratio; LVEF, left ventricular ejection fraction; MI, myocardial infarction; MP, myocardial perfusion; PCI/CABG, percutaneous/surgical coronary revascularization; WM, wall motion.

Statistically significant predictor.