Table 1.
Baseline characteristics of participants by renal function
| Characteristic | Progressors | Nonprogressors |
|---|---|---|
| Number of participants (%) | ||
| All participants in category | 390 | 1697 |
| Women | 236 (60.5)a | 732 (43.1) |
| Diabetes mellitus | 358 (91.8)a | 1175 (69.2) |
| Hypertension | 110 (28.2)a | 278 (16.4) |
| UAE ≥20 μg/min | 40 (10.3)b | 89 (5.2) |
| CDK273 signal ≥0.154 and <0.343 | 34 (8.7)c | 99 (5.8) |
| CKD273 signal ≥0.343 | 54 (13.8)a | 76 (4.5) |
| Mean of characteristic | ||
| Age (yr) | 55.2 ± 11.7a | 44.0 ± 15.0 |
| Systolic pressure (mm Hg) | 131.4 ± 14.8a | 124.7 ± 14.4 |
| Diastolic pressure (mm Hg) | 77.3 ± 7.5 | 76.8 ± 8.3 |
| Mean arterial pressure (mm Hg) | 95.4 ± 8.8a | 92.7 ± 9.2 |
| Serum creatinine (μmol/L) | 87.5 ± 12.4 | 88.4 ± 12.4 |
| eGFR (ml/min per 1.73 m2) | 73.0 ± 9.93a | 82.8 ± 12.9 |
| UAE (μg/min)c | 6.76 (3.50 to 9.51)a | 5.24 (3.12 to 7.08) |
| CKD273 | –0.17 ± 0.43a | –0.40 ± 0.41 |
| Follow-up (yr) | 4.73 (4.22–4.94)a | 4.50 (4.16–5.11) |
| eGFR data points | 6 (5–6)a | 5 (2–6) |
Averages are arithmetic means ± SD or geometric means (interquartile range). Estimated glomerular filtration rate was derived from serum creatinine by the Chronic Kidney Disease Epidemiology Collaboration formula.
CKD273, urinary proteomic biomarker; eGFR, estimated glomerular filtration rate; UAE, urinary albumin excretion rate.
Progressors had an eGFR decrease by at least 10 ml/min per 1.73 m2 to less than 60 ml/min per 1.73 m2. P values indicate significance of the difference between progressors and nonprogressors.
a
P ≤ 0.0001.
b
P ≤ 0.001.
c
P ≤ 0.05.