Fig. 4. Three-dimensional co-localization of Fe and dopaminergic brain regions. (a) TH expression measured by ISH is available from the Allen Reference Atlas and Brain Explorer 2 platform. Comparing the 2–4th quartile ranges for both ISH data (density = 0.45–0.1 units) and 173Yb (>5000 counts per second; (b)) shows general agreement with TH expression in olfactory bulbs and mesencephalon. High Fe (>25 μg g–1; (c)) is also found in these regions, and colocalises with TH generally in the olfactory bulbs, and specifically in the substantia nigra pars compacta region (black arrows; (d)) of the midbrain.
