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. 2017 Jan 16;37(11):3599–3614. doi: 10.1177/0271678X16685573

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — MRI reports the acute microinfarct core. (a,b) IR and MK image of two microinfarcts 24 h after penetrating vessel occlusion. The upper and lower microinfarcts have resulted from arteriole and venular occlusions, respectively. (c) Mice were sacrificed for post-mortem histology immediately following MRI. NeuN staining was performed to identify the extent of the microinfarct core (yellow dotted line). (d, e) Scatterplot of microinfarct area measured in histology versus area of the same microinfarct measured in vivo with IR (p = 1.5 × 10⁻⁷, R²= 0.91; Pearson’s correlation) or DKI (p = 1.7 × 10⁻⁷, R²= 0.90; Pearson’s correlation). Data are from n = 8 penetrating arteriole and n = 6 penetrating venule occlusions over eight mice. Green data points correspond to microinfarcts generated by off-target control irradiations.