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. 2017 Jan 16;37(11):3599–3614. doi: 10.1177/0271678X16685573

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 7. — Disruption of single-vessel hemodynamics in peri-lesional tissues surrounding microinfarcts. (a–c) Sensory-evoked dilation as a function of distance from the microinfarct core (red; n = 50, 36, and 24 arterioles over six mice for panels a, b, and c, respectively). Open circles represent surface arterioles, and filled circles represent penetrating arterioles. An off-target control group showed no change in dilatory function beyond the region of photothrombotic irradiation (green in panel a; n = 33 arterioles over three mice). Lines correspond to second order polynomial regression fits of the data. (d) Mean change in diameter during whisker stimulation over a group of arterioles that could be measured repeatedly over all time-points (p < 0.0001 main effect, Friedman statistic = 82.1, Friedman test with repeated measures; Dunn’s post hoc yields ****p < 0.0001 or ***p < 0.001, compared to pre-occlusion, and ^#p < 0.05, compared to 2 to 3 days; n = 36 arterioles over six mice). Data are mean ± SEM. (e) Latency to peak dilation after onset of stimulation (p < 0.0001 main effect, Friedman statistic = 82.6, Friedman test with repeated measures; Dunn’s post hoc yields ****p < 0.0001, compared to pre-occlusion, and ^#p < 0.05, compared to 2 to 3 days and 7 to 9 days). (f) Baseline diameter of arterioles prior to stimulation. (p < 0.0001 main effect, F(2.42,84.58) = 8.96, one-way ANOVA with repeated measures; Tukey’s post hoc yields ****p < 0.0001, compared to pre-occlusion). (g) Mean change in diameter after inhalation of vasodilating anesthetic isoflurane (3% MAC in air) (p < 0.0001 main effect, Friedman statistic = 39.9, Friedman test with repeated measures; Dunn’s post hoc yields ****p < 0.0001 or ***p < 0.001, compared to pre-occlusion).