Fig. 1.

The figure depicts the pattern that was drawn on the skin to guide the injections. Tibialis anterior muscle was injected at a right angle to the muscle with a depth of 3 mm. Plasmid DNA was injected at 1, 3, 5 or 7 sites indicated by a filled circle. Hyaluronidase or vehicle, marked with an open circle, was injected at 2 sites in all experiments.